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KMID : 0360120080300040395
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Journal of the Korean Society of Maxillofacial Plastic Reconstructive Surgeons
2008 Volume.30 No. 4 p.395 ~ p.398
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Bisphosphonate(zoledronic acid) related osteomyelitis on mandible: a case report.
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Lee Su-Youn
Choi So-Young
Kim Jin-Wook
Kwon Tae-Geon
Jang Hyun-Jung
Kim Chin-Soo
Lee Sang-Han
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Abstract
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Bisphosphonate are a class of drugs with a chemical structure which inhibit bone resorption, actually used for metastatic bone disease, osteoporosis, Paget’s disease and multiple myeloma. Significant complication associated with their use is reported recently : mandibular and maxillary osteomyelitis or osteonecrosis. So we here report our case about the patient who was diagnosed of prostate cancer in 2004 April and treated with bisphosphonate(Zoledronic acid-Zometa(R), Novartis Co.) intravenously every 3 to 4weeks at a dose of 4mg to prevent bone metastasis, and also, the patient who came to the hospital due to the bony exposure of mandible and pain in 2006 November and was diagnosed osteomyelitis of mandible as a result of biopsy, bone scan, PET CT examination.
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KEYWORD
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Bisphosphonate, Mandibular osteomyelitis, Prostate cancer, Metastatic bone disease
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